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The 1982 Chicago Tylenol Murders were a string of drug-related poisoning killings in the Chicago metropolitan region.

The 1982 Chicago Tylenol Murders were a string of drug-related poisoning killings in the Chicago metropolitan region. All of the victims had consumed acetaminophen capsules bearing the Tylenol brand that had been tainted with potassium cyanide. The initial poisonings resulted in seven deaths, while subsequent copycat acts resulted in several further fatalities.

The poisonings have neither been charged with nor linked to any suspects. James William Lewis, a resident of New York City, was found guilty of extortion for writing to Johnson & Johnson, the company that makes Tylenol, claiming responsibility for the deaths and demanding $1 million to put an end to them. However, there was never any proof linking Lewis to the actual poisoning.

The occurrences prompted changes to over-the-counter drug packaging and the enactment of federal anti-tampering statutes.

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