The given point is (2,1), and the vertex is (4, -2). This means h = 4, and k = -2.
To find the equation, we have to find the parameter a with the given information and the vertex form.
[tex]y=a(x-h)^2+k[/tex]Let's replace the given point and the vertex.
[tex]\begin{gathered} 1=a(2-4)^2-2 \\ 1+2=a(-2)^2 \\ 4a=3 \\ a=\frac{3}{4} \end{gathered}[/tex]Now, we replace the parameter a and the vertex to find the equation of the parabola.
[tex]y=\frac{3}{4}(x-4)^2-2[/tex]The image below shows the parabola.