ORF alignments above a certain threshold level with one or more genes in the database are presumed to encode a protein of similar function and such pairs are called Orthologues. They diverged by speciation.
What are orthologue genes?
Orthologue genes are genes that evolved by divergence from a common ancestor.
In general, orthologue genes have the same function in different species, but they exhibit sequence variation.
The alignment between orthologue genes exhibits sequence homo-logy in evolutionarily conserved gene regions.
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