Answer:
Tolerance means that due to repititve use of the drug, initial dose is unable to prpduce the same effect beacuse the receptors has been desensitized.
If An initial dose is 100 mg then dose higher than this which may be 2 or 3 times more potent may reverse this tolerance of the drug and it may then produce similar effects at a higher dose.
Explanation:
Tolerance is said to be the decreased response by the drug because of the continuous exposure to the drug at the receptor molecules. Due to this contionuous exposure the receptors become desensitized.
Tolerance occurs when the person no longer responds to the drug in the way that person initially responded. Tolerance can be reversed by increasing the dose of the drug lets say initial dose was 100 mg. To reverse the tolerance, a dose of 500 mg may be required or even more.
