Answer:
The answer is very likely 1.
Explanation:
Going into a little bit of detail to justify this will be simple. The reason 1. is the best answer is because any change or alteration in our DNA is considered a mutation. We must remember that mutations are not always helpful or detrimental (harmful) to the individual. This helps us exclude 2. There are also some mutations that can occur which are not captured by chromotography. For example silent mutations, are those mutations that can occur within a DNA molecule that does not change the effect of a protein. Which is what chromatography generally is used for - separating proteins - so 4 is out. As for 3, remember that sometimes a mutation can occur during DNA synthesis or maybe even mitosis - but we have a way inside our cells to fix those mutations - which means that it is not always passed to offspring; that leaves us with just one option - 1. There is some technicality in all of this - so hopefully I'm following the teachers train of thought.
