Futile resistance is the immunity system and HIV infections. HIV infection results in immunodeficiency because it acts as infects helper of T cells and its reception is CD4. Again immunodeficiency is a helper of T cells which are destroyed and the host can’t develop an immune response.
We have primary immunodeficiency which is a developmental and genetic defect in immunity. Secondary immunodeficiency results from damage to immune cells after developing normally. For example cancer, leukaemia and HIV. Effect of immunodeficiency appears sick all the time.