Question

Immediately after dna replication a dna repair mechanism scans the dna for incorrect base pairs. upon which feature of the dna molecule does the repair mechanism rely to indicate incorrect bases?

Answer 1

The answer is proofreading feature of DNA polymerase.  As the DNA polymerase III replicates DNA, it has a proofreading mechanism in one of the subunits of the holoenzyme. This subunit detects a bad conformation in the double helix when the wrong base pair is placed. In this case, the DNA polymerase III backs up a bit and waits for the exonuclease to nick out the misplaced base.

Answer 2

The feature of the DNA molecule that allows repairing incorrect bases is DNA proofreading.

What is DNA proofreading?

DNA proofreading is a feature of some DNA polymerases that allows correct errors during DNA replication.

• During this process, (DNA proofreading) the enzyme DNA polymerase reads nucleotide bases before adding other bases.

• In consequence, the DNA polymerase checks for errors before adding new bases.

In conclusion, the feature of the DNA molecule that allows repairing incorrect bases is DNA proofreading.

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