Secretin stimulates the pancreas to secrete bicarbonate. While Cholecytokin in CCKstimulates the pancreas to secrete pancreatic enzymes. Secretin is a hormone that regulates water homeostasis throughout the body and influences the environment of the duodenum by regulating secretions in the stomach, pancreas, and liver. It is a peptide hormone produced in the S cells of the duodenum, which are located in the intestinal glands. The principals target for secretin is the pancreas, which responds by secreting a bicarbonate-rich fluid, which flows into the first part of the intestine through the pancreatic duct.
