If ribonucleotides were depleted from a cell during s phase, how would dna synthesis be affected? (ignore energetic considerations.) dna synthesis would continue, but at a slower rate. there would be no effect because ribonucleotides are used in rna synthesis, not dna synthesis. dna synthesis would not be affected because ribonucleotides are only used during the process of transcription. there would only be an effect during m phase, not in s phase. replication would cease because ribonucleotides are required to initiate dna synthesis.