heterodimeric protein that initiates prophase of mitosis and alters the activity of diverse proteins that function in mitosis by phosphorylation; active MPF contains both cyclin B (large) and cyclin-dependent kinase 1 (small) subunits. Activity is regulated partly by the synthesis and degradation of cyclin B subunit
Maturation-promoting factor (abbreviated MPF, also called mitosis-promoting factor or M-Phase-promoting factor) is the cyclin-CDK complex that was discovered first in frog eggs. It stimulates the mitotic and meiotic phases of the cell cycle.
