Question

For the hydrolysis of atp to adp + i, the free energy change is -7.3 kcal/mol under standard conditions (1 m concentration of both reactants and products). in the cellular environment, however, the free energy change is about -13 kcal/mol. what can we conclude about the free energy change for the formation of atp from adp and i under cellular conditions?

Answer 1

We can conclude that there is a much higher [ATP] than [ADP + Pi] normally in cells, which favors the hydrolysis pathway.
In other words, reactants (ATP) >> products (ADP + Pi), which creates a more negative G.
ΔG = G(products) - G(reactants)