After getting a B.S in computer programming in 1985, and then missing some time in between jobs, you will need to make a new resume. Since you already have worked several jobs, and two with major companies, you will want to list those on the top of the resume. The most appropriate strategy for dealing with your resume and the irregular work history will not be very complicated. You will want to include all of the dates of employment and any recognition/awards you may have received with those jobs. Next, you will want to explain in the application letter that you were not in the workforce because of your childcare responsibilities. You may also want to include that the children are now in school, and you can focus on your career.