What is a novel virus that causes respiratory disease in children is determined to have a single-stranded RNA genome and to lack enzymatic activities in the virus particles?

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Answer: A novel virus that causes respiratory disease in children and is determined to have a single-stranded RNA genome and lacks enzymatic activities in the virus particles could be a virus from the family Picornaviridae. Examples of viruses in this family include Enterovirus and Rhinovirus. These viruses typically have single-stranded RNA genomes and lack enzymatic activities in their viral particles.

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