Question

Holoprosencephaly is most often associated with which of the following?
A. Autosomal recessive polycystic kidney disease
B. Triploidy
C. Down syndrome
D. Trisomy 13
E. Trisomy 21

Answer 1

Answer:

D) Triploidy

Explanation:

D. Trisomy 13

Holoprosencephaly is a congenital disorder characterized by the incomplete separation or fusion of the cerebral hemispheres. It often presents with facial abnormalities and severe intellectual disabilities. Trisomy 13, also known as Patau syndrome, is strongly associated with holoprosencephaly. Trisomy 21, or Down syndrome, is not typically associated with holoprosencephaly, although both conditions can be present in rare cases of chromosomal abnormalities.