Answer:
There are some 38 diseases that can be listed caused for the malfunctioning of the hormones depending on the system involved.
Explanation: Starting from The common disease diabetes , Type 1 Diabetes
Type 2 Diabetes, to several more.the hormones work either together or else alone and keep many systems and functions in check and working to their optimum limits.So its not just the organs that is synthesising which is affected but at the site of action, several hormones act on several enzymes and so a complicated effect is seen, as I said some 48 diseases and may be more incase I have missed counting a few.