Question

Estimates are that p53 is mutated in 50% of all human cancers. If the gene that encodes p53 is mutated such that p53 is non-functional, what processes would be affected? Check all that apply.

A. The ability to halt the cell cycle in response to DNA damage.
B. The ability to halt the cell cycle in response to the chromosomes not properly aligning on the metaphase plate.
C. The ability to repair DNA damage.
D. The ability to activate Cdks.
E. The ability to stimulate cell death processes if the cell is irreparably damaged.

Answer 1

TP53 or tumor protein or p53 functions as tumor suppressor. It is described as "the guardian of the genome". Its molar mass is 53 kilodalton fraction of cell proteins, thus, the name p53


A. The ability to halt the cell cycle in response to DNA damage.
C. The ability to repair DNA damage.
E. The ability to stimulate cell death processes if the cell is irreparably damaged.