Dopamine overactivity appears to be most clearly related to hallucinations.
There is proof that very high levels of dopamine in the limbic system play a significant role in the formation of hallucinations and delusions in schizophrenia (SCZ). Antipsychotic drugs, which inhibit central dopamine action, lessen psychotic hallucinations.
The main symptom of psychotic disorders, hallucinations, are thought to be caused by the brain's overproduction of dopamine. However, because hallucinations have proven difficult to investigate in model organisms, the brain circuit mechanisms through which dopamine causes them continue to be a mystery.
According to studies, people with schizophrenia who experience auditory hallucinations frequently hear what they anticipate hearing, which is an amplified variation of a perceptual distortion that is typical of people who do not experience hallucinations.
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