The dorsal telencephalon's ventricular zone gives rise to excitatory projection neurons, which move radially to the cortical plate.
The MGE, AEP/POA, in particular, in the ventral telencephalon is the source of inhibitory interneurons. The efferent pyramidal cells, which are the most numerous neurons, are organized vertically throughout the majority of the cerebral cortex's neurons (very large giant pyramidal cells found in the layer V of the regions of the motor cortex are called Betz cells).
Excitatory neurons migrate toward their final places in the cerebral cortex, where they develop a distinct layered structure, from where they are born in the ventricular zone (VZ) facing the ventricle.
In order to fit a large cortex into a small cranial volume and to maximize the functional structure and wiring of the brain, cortical folding occurs during embryonic development.
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