MHC genes are the most polymorphic of any in the human genome. Which of the following statements about MHC polymorphism is true? a. HLA-A, HLA-B, and HLA-C represent three different alleles of the same gene.
b. Most of the polymorphic residues in any MHC protein are located in the peptide binding groove.
c. Only class I MHC genes are polymorphic; class II MHC genes are not.
d. Many unrelated people have identical MHC alleles
e. MHC polymorphism is a result of somatic recombination of inherited nonpolymorphic MHC gene segments.

The correct statement about MHC polymorphism is "HLA-A, HLA-B, and HLA-C represent three different alleles of the same gene". Hence, option A is correct.

MHC polymorphism is defined as the extension of the range of antigens to which the immune system can respond. Most of the polymorphic genes encodes the proteins that vary by only one or a few amino acids, whereas the different allelic variants of MHC proteins differ by up to 20 amino acids.

The variations caused in the MHC molecules (responsible for the polymorphism) are the result of the inheritance of different MHC molecules, and they are not induced by recombination, as it is the case for the antigen receptors.

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