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The Missouri Compromise of 1820 was an attempt to defuse increasing social tensions over the issue of slavery that were impeding its admission.

The Missouri Compromise succeeded in maintaining the peace for the time being, but it was unable to address the crucial issue of slavery and its future in the country. The Missouri Compromise was opposed by the South because it established a precedent for Congress to pass legislation pertaining to slavery, and by the North because it implied the spread of slavery into new areas.

The issue of the spread of slavery continued to split the country in the decades after 1820, during which time westward migration increased and more areas acquired via the Louisiana Purchase were divided into territories. California was obligated by the Compromise of 1850, which allowed it to join the Union as a free state, to send one pro-slavery senator in order to keep the Senate's political balance in its favor.

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