Respuesta :
Step 1 produces 5-phosphoribosyl-a-pyrophosphate (PRPP) by directly transferring a pyrophosphoryl group from ATP to the C-1 of the ribose (Figure 27.3). Ribose-5-phosphate pyrophosphokinase is the enzyme.
The limiting component in purine biosynthesis is PRPP. This method for purine synthesis consists of three main stages. Ribose-5-P, a byproduct of the Hexose MonoPhosphate Shunt or Pentose Phosphate pathway, serves as the precursor for purine biosynthesis (HMP Shunt). Pyrophospho Kinase converts ribose-5-P into phosphoribosyl pyrophosphate in this process, which uses up ATP. Glutamine phosphoribosyl pyrophosphate amidotransferase catalyzes Step 2 (Figure 27.3). The result is a b-glycoside; the anomeric carbon of the substrate PRPP is in the a-configuration (recall that all the biologically important nucleotides are b-glycosides).
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