The beta-2 adrenergic receptor is a membrane-bound protein that regulates several cellular processes, including the synthesis and breakdown of glycogen. The receptor binds specifically to the hormone epinephrine. The binding of epinephrine to the beta-2 adrenergic receptor triggers a signal transduction cascade that controls glycogen synthesis and breakdown in the cell. A simplified model of the signal transduction cascade is represented in Figure 1.Figure 1. A simplified model of the signal transduction cascade triggered by epinephrine binding to the beta-2 adrenergic receptorWhich of the following outcomes will most likely result from the inactivation of the beta-2 adrenergic receptor?A. The cellular concentration of cyclic AMPAMP will increase.B. The enzymatic activity of protein kinase A will increase.C.The activation of glycogen phosphorylase will increase.DThe rate of glycogen synthesis in the cell will increase.

Based on Figure 1, activation of beta-2-adrenergic receptors causes stimulation of glycogen breakdown and inhibition of glycogen synthesis. The immediate effect of the deactivation of beta-2-adrenergic receptors is an increase in the rate of glycogen synthesis in cells because glycogen synthesis is no longer inhibited. Glycogen breakdown in cells is also no longer stimulated, because glycogen phosphorylase may be deactivated.

This question is multiple choice:

A. The cellular concentration of cyclic AMPAMP will increase.

B. The enzymatic activity of protein kinase A will increase.

C. The activation of glycogen phosphorylase will increase.

D. The rate of glycogen synthesis in the cell will increase.

The true choice is D

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