rtt105 configurationally staples rpa and blocks facilitated exchange and interactions with rpa-interacting proteins

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shelbs2058 shelbs2058

16-12-2022
Biology

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rtt105 configurationally staples rpa and blocks facilitated exchange and interactions with rpa-interacting proteins

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tutorconsortium631 tutorconsortium631 · Answer 1 · 2022-12-20T13:23:57+01:00

To coordinate several parts of DNA metabolism, including DNA replication, Replication Protein A (RPA) attaches to single-stranded DNA (ssDNA) and recruits approximately three dozen (RIPs).

What role does the protein RPA play in the initial strand invasion process?

Thus, it appears that RPA contributes to strand invasion and helps Rad51 bind to ssDNA, perhaps by stabilizing the displaced ssDNA.

What function does RPA serve in eukaryotic recombination processes?

To control DNA replication, recombination, and repair, RPA binds to single-stranded DNA (ssDNA) avidly via a variety of oligonucleotide/oligosaccharide-binding folds. It also orchestrates the recruitment and exchange of genome maintenance proteins.

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