Please identify the four most significant interactions between humans and the microbes that live in and on our bodies. Microbes promote the development and maturation of host immune defenses. Microbes may invade and grow in normally sterile body sites. Microbes cause disease by damaging tissues and organs.

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In addition to positive connections in the form of human, domestic animal, and crop diseases, human interactions with microorganisms also involve both practical and symbolic uses of germs.

Fermentation in food processing was the first practical application of microbes in antiquity; yeasts have been used to make bread, beer, and wine since the birth of civilization, including in ancient Egypt. More recently, as industrial chemists learn how to produce an increasing variety of organic chemicals, including enzymes and bioactive molecules like hormones and competitive inhibitors for use as medicines, microbes have been used in activities ranging from biological warfare to the production of chemicals by fermentation. Additionally, fuels can be created through fermentation, including ethanol and methane, which are alternatives for fossil fuels .Escherichia coli and yeast are used as model organisms in scientific research, particularly in genetics and related sciences.

Pathogens, or microorganisms that cause disease in humans, domesticated animals, and crop plants, include bacteria, viruses, and other microorganisms.

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