If you wanted to have an injectable drug to treat a brain tissue disorder a a lipid-soluble drug is most effective.
So the correct answer is option B.
The lipoid cell membrane makes it easier for lipid-soluble medications to diffuse into cells. Sometimes bigger molecules move across membranes more slowly than smaller ones. Most medications are weak organic acids or bases that can be found in ionized and unionized aquatic environments. Because the unionized form is typically lipid soluble, it diffuses across cell membranes with ease (lipophilic). The ionized form's limited lipid solubility and high electrical resistance make it challenging to cross cell membranes (but high water solubility, or hydrophilicity).
Because they may more easily cross the blood-brain barrier, lipid-soluble drugs should be more likely to have adverse effects on the nervous system, such as interrupting sleep.
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