Question

One way to model drug abuse in animals is to allow rats to self-administer narcotics by pressing a lever. Suppose a new drug is injected into a group of rats that have been self- administering cocaine. After the injection, the rats show a significant reduction in the number of times they press the lever to receive cocaine. Which of the following would be a valid argument about the new drug based on this result? O The drug may be an effective way to help a human fight a cocaine addiction. The drug will have no effect on humans. The drug will definitely reduce cravings in humans addicted to cocaine. The drug will be as addictive as cocaine for humans.

Answer 1

The drug may be an effective way to help a human fight a cocaine addiction would be a valid argument about the new drug based on this result.

Understanding the behaviour of human drug users is challenging after studying addiction in animals. Treatment options are largely unchanged despite years of basic research on the neurological causes of drug addiction. This situation may be caused, in part, by the fact that mechanistic studies employing rodent models do not take into account a crucial aspect of human addiction: volitional choices among drug use and social rewards that do not include drugs.

Rats in this operant model press a lever to gain rewarding peer social interaction or addictive substances. The model can therefore be applied to research the susceptibility of addiction in the context of choices as well as the function of operant social reward in addiction.

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