It is true that interferon priming is essential for human CD34 cell-derived plasmacytoid dendritic cell maturation and function.
Immune competence is dependent on plasmacytoid dendritic cells (pDC). When TLR7 and TLR9 agonists are administered, pDC precursor differentiated from human CD34+ hematopoietic stem and progenitor cells (HSPC) exhibits a low surface expression of pDC markers and limited induction of type I interferon (IFN) and IL-6; cGAS or RIG-I agonist-mediated activation, on the other hand, is unaffected. Importantly, this precursor pDCs acquire a phenotype and functional activity that are comparable to those of pDCs derived from peripheral blood following priming with type I and II IFN.
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