Question

glucose transporter (glut) isoforms move glucose in and out of the cell. gluts respond to the glucose equilibrium concentrations. use your knowledge of enzyme catalysis and kinetics to predict which of the following correctly rank the steps in glucose transport by glut1? i. glucose binding results in a conformational change, opening the binding site on the opposite side of the membrane ii. glucose binds to the transporter on one side of the membrane iii. the transporter reverts to initial conformation iv. the glucose disassociates

Answer 1

The correct order of glucose transport by GLUT1 is:

1. Glucose binds to a transporter on one side of the membrane.
2. When glucose binds, it undergoes a conformational change, opening the binding site on the opposite side of the membrane.
3. Glucose dissociates from the transporter.
4. The transporter reverts to its original structure.

In enzyme catalysis and kinetics, the binding of the substrate (glucose in this case) to the enzyme (GLUT1) is the first step in the reaction.

This is followed by a conformational change in the enzyme that allows transport of the substrate across the membrane.

Once the substrate has been transported, it is released and the enzyme returns to its original conformation, ready to bind and transport more substrate.

Read more about glucose transport at:

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