The modification that has taken place in the cells of the disease patients is an epigenetic modification (DNA methylation).
Epigenetic modification marks are chemical groups that are added to the DNA on cytosine bases and or the associated histones, which in this last case include acetylation of histones, methylation of histones, ribosilation, etc.
These marks (epigenetic modification marks) act to shape gene expression patterns in the cell and it has been shown that aberration of epigenetic modification marks may lead to different disease states including distinct types of cancer and metastatic tissues.
Therefore, with this data, we can see that epigenetic modification marks may shape gene expression in the cell and therefore modification in the state of these marks may be associated with disease states as well as the expression of certain genes in the development of a cell.
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