The va/vl thalamic nucleus are under the tonic (constant) inhibition of the globus pallidus.
Therefore, the subthalamus is disinhibited as a result of the striatum's functional inhibition of the external globus pallidus. Because of this, the subthalamic neurons become more active, stimulating the globus pallidus' internal segment, which ultimately suppresses the thalamic nuclei. The indirect pathway produces, or reinforces, the normal inhibition of the thalamus, whereas the direct pathway results in the dysregulation of a thalamus nucleus (inhibition of one cell on a target cell that subsequently inhibits the first cell). The principal output of the BG is provided by GABAergic neurons of the pars reticulata, which inhibit thalamic neurons, as well as dopaminergic nucleus of the pars compacta, which regulate thalamic excitability. Together, these two types of neurons make up the substantia nigra (SN).
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