The most appropriate reagent(s) for the conversion of trans-4-tert-butylcyclohexanol to the corresponding tosylate ester is Chromic acid.
What is Chromic acid?
Chromic acid anodizing has been used to protect aluminum from oxidation for many years. The anodizing process builds a basic oxide layer that supports a tubular cell structure. Chromic acid (H2CrO4) reacts with alcohols to form a chromic ester in which the alcohol oxygen atom bridges the carbon and chromium atoms. The ester forms by nucleophilic attack of the alcohol oxygen atom on the chromium atom. This reaction is analogous to an SN2 reaction with an a─OH group of chromic acid as the leaving group.
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