Question

An organism is born with a mutation that results in ATP synthase (See figure) being entirely hydrophilic. Which of the following is likely to result from this mutation?
- The mutation will result in a severe decrease in the production of ATP leading to death.
- The mutation will prevent glycolysis from occurring within the organism.
- All of the above

Answer 1

An organism is born with a mutation that results in ATP synthase being entirely hydrophilic, the mutation will result in a severe decrease in the production of ATP leading to death.

With some of its subunits being water soluble and others being essential membrane proteins, the ATP synthase is attached to the inner membrane of the mitochondrion.

F1 (factor 1) and Fo are the two distinct parts of the mitochondrial ATP synthase (a factor that confers sensitivity to oligomycin). A proton turbine (inside Fo) and a molecular machine (F1) that uses rotational energy to create ATP from ADP and phosphate make up the reversible molecular motor known as the ATP synthase. The flow of protons along a potential gradient across the mitochondrial membrane produced by the electron transport chain during respiration drives the proton turbine.

Learn more about ATP synthase at:

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