The several ways how an immune system can defend the body against pathogens are:
1) Mechanical and chemical barriers as the first line of defense
2) The inflammatory response and phagocytosis are the second line of defense.
3) Natural killer cells and specific immunological responses serve as the third line of defense.
There are three layers of defense in immune function, which is the internal environment's defense against invading cells, proteins, and viruses. A series of barriers between the internal and external environments serves as the initial line of defense.
The innate inflammatory response (including phagocytosis) makes up the second line, while the adaptive immune responses and the innate defense provided by natural killer cells make up the third line.
Of course, the first two lines of defense do not apply to tumor cells that develop inside the body, thus the third line of defense must be used to combat them. This illustration is a condensed version of the complex immune system operation; in reality, there is a lot of mechanism overlap between various "lines of defense."
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