acetyl chloride > acetic anhydride > methyl acetate > acetamide is the correct order of decreasing reactivity in nucleophilic acyl substitution reactions.
Nucleophilic acyl substitution reaction is the term used to describe this type of substitution reaction where the acyl molecule and nucleophilic acyl interact. The nucleophile and carbonyl molecules interact with one another in this reaction through an addition reaction. Based on the leaving group's state, which is influenced by the compounds' acidity, acyl compounds are reactive. Acetyl chloride > acetic anhydride > methyl acetate > acetamide is the decreasing order of reactivity for the acyl compounds.
The acyl chloride that comes from acetic acid is called acetyl chloride. This organic chemical is a member of the acid halide class. The liquid is volatile, colourless, and corrosive. Commonly abbreviated as AcCl, it has the following formula. A fuming liquid with a strong odour and a colourless to pale yellow hue is acetyl chloride. Both medications and insecticides are produced using it.
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