The statement "Interactions of the hydrophobic and hydrophilic amino acids help to anchor the protein in the membrane." explains why protein folding is important. This process is fundamental to the function of transmembrane proteins.
Protein folding refers to the process by which a polypeptide (ie, protein) adopts its final 3D three-dimensional shape (conformation).
In proteins, some amino acids contain hydrophilic R groups and others contain hydrophobic R groups.
During protein folding, hydrophobic amino acids are arranged to interact with long-chain fatty acids inside the lipid bilayer and hydrophilic amino acids are arranged to interact with water at the surface of the cell membrane. detailed:
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