when acetylcholine binds postsynaptic nicotinic acetylcholine receptors, each receptor causes its own postsynaptic voltage change, which is called an end-plate potential. the summation of the end-plate potentials represents the membrane potential. the synaptic acetylcholine concentration influences the amplitude of end-plate potentials.

An ion pore is created in the receptor as a result of a conformational shift brought on by the binding of two acetylcholine molecules to a nicotinic AchR.

Acetylcholine binds to the nicotinic receptors localized on the motor end plate, a specific region of the post-synaptic membrane of the muscle fiber. The nicotinic receptor channels open as a result of this binding, allowing sodium ions to pass into the muscle fiber. Acetylcholine diffuses across the synaptic cleft after being released from synaptic vesicles and binds to acetylcholine receptors on the postsynaptic membrane. The acetylcholine receptor is a pentameric protein made up of five subunits. Acetylcholine binds to the nicotinic receptors concentrated on the motor end plate, a specific region of the post-synaptic membrane of the muscle fiber. The nicotinic receptor channels open as a result of this binding, allowing sodium ions to pass into the muscle fiber. The adrenal cortex contains nicotinic cells, which produce hormones. Both sympathetic and parasympathetic preganglionic neurons are all nicotinic.

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