fructose-6-phosphate; fructomannose isomerase
Mannose first undergoes phosphorylation by hexokinase before entering glycolysis. The phosphomannose isomerase enzyme then isomerises the freshly generated mannose-6-phosphate into fructose-6-phosphate. The sugar can now follow the typical glycolytic pathway because it is in the right shape.
Through fructose-1-phosphate, glucose enters the glycolytic route, mannose is phosphorylated to become mannose-6-phosphate, and galactose is enzymatically changed into glucose-6-phosphate.
Although both enzymes can phosphorylate other hexoses including fructose and mannose, they can also support development on glucose.
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