Feedback inhibition is the inhibition of an enzyme by a reaction product. As more glucose-6-phosphate is produced, the rate of reaction slows. Hexokinase governs the rate-limiting step of glycolysis in the brain and red blood cells.
Feedback inhibition regulates glycolysis. Cellular respiration is a multi-step process, including glycolysis, the citric acid cycle, and oxidative phosphorylation. Like many biochemical pathways, it is controlled in part by feedback inhibition: ATP, the end product of OXPHOS, inhibits the initiation of glycolysis. ATP, for example, is a "stop" signal: high levels mean the cell has enough ATP and doesn't need to make more through cellular respiration. This is a case of feedback inhibition, where a product "feeds back" to itself to close its path. Feedback inhibition is when a reaction product is used to regulate its own further production. Cells have evolved to use feedback inhibition to regulate enzyme activity in metabolism, using the products of enzyme reactions to inhibit further enzyme activity.
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