The liver is in charge of metabolizing and detoxifying foreign substances, including medications, in the blood.
Numerous medicines are metabolised by the liver, and as a result, water-soluble molecules that can be eliminated in the bile are produced. This is the consequence of phase 1 reactions, such as oxidation, reduction, and hydrolysis reactions, which are mediated by cytochrome p450. Phase 2 reactions, which are conjugative, come next.
A class of enzymes known as cytochrome P450 performs oxidation and reduction activities (phase 1) using iron to increase the solubility of medicines in water, which helps with excretion. Because they are attached to cell membranes and have a haem pigment that absorbs light at a wavelength of 450 nm when exposed to carbon monoxide, CYP450 enzymes get their name.
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