The central nervous system is both stimulated and depressed by nicotine.
Nicotine is a toxic and very addicting substance. It may result in an increase in heart rate, blood flow to the heart, blood pressure, and the constriction of arteries, among other things (vessels that carry blood). Nicotine may also aid in the hardening of artery walls, which could result in a heart attack.
Compared to the "high" associated with other medicines, this spike lasts far less time. However, nicotine, like other addictive substances, elevates dopamine levels in these reward circuits,20,21,27 reinforcing drug-taking behavior.
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