High dosages of exposure can result in delirium and confusion. Abusers of inhalants may also experience stupor, generalized muscle weakness, depressed reflexes, lethargy, dizziness, and drowsiness.
Among the medical anesthetics are nitrous oxide, ether, chloroform, and halothane (commonly called "laughing gas"). Inhalants have effects that are comparable to anesthesia.
By directly stimulating Ventral Tegmental Area Neurons, the abused inhalant toluene increases dopamine release in the nucleus accumbens | Neuropsychopharmacology. Sedation, refractory bronchospasm, and treatment of status epilepticus unresponsive to anticonvulsant drugs are the main uses of inhaled anesthetic agents in the ICU.
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