The genetically engineered mice were bred to express fewer of these receptors to provide an animal model of the glutamate hypothesis of schizophrenia was triggered by NMDA receptors.
What is gene?
Parent to child transmission of the fundamental component of heredity. The chromosomes in the nucleus of cells contain specific locations where the DNA sequences that make up genes are arranged in a logical order, one after another.
What is schizophrenia?
Chronic recurrent psychotic illness schizophrenia typically first manifests in adolescence and lasts a lifetime. 1,2. Cognitive dysfunction and negative symptoms are examples of prodromal symptoms, which frequently occur before acute psychosis.
The clinical/behavioral finding that NMDA receptor antagonists can cause psychosis in humans and abnormal behavior with symptoms similar to those of schizophrenia in animals led to the development of the glutamatergic hypothesis of schizophrenia. Initial theories highlighted NMDA receptor hypofunction as a potential pathogenetic mechanism.
Therefore, genetically engineered mice were bred to express fewer of these receptors to provide an animal model of the glutamate hypothesis of schizophrenia was triggered by NMDA receptors.
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