The loss of total body sodium leads to volume depletion, also known as extracellular fluid (ECF) volume contraction. The use of diuretics, excessive perspiration, diarrhoea, burns, and renal failure are among the causes.
Water will move from the cell into the extracellular space to balance the osmotic gradient if the ECF osmolarity rises due to a disruption; nonetheless, the total body osmolarity will stay higher than usual, and the cell will contract.
The creatinine urine test quantifies the creatinine content of the urine. A blood test can also be used to measure creatinine.
Inadequate ECF volume primarily impairs cardiovascular function by reducing plasma volume and, in certain circumstances, by resulting in circulatory shock.
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