Once heterochromatin has been established, it will often spread until it encounters (A) a barrier DNA sequence. So option (A) is the correct answer.
The shape of chromatin in which sections of interphase chromosomes reside is highly dependent on histone tail modifications. When heterochromatin-specific proteins bind to chromosomes, they also tend to modify the tails of adjacent nucleosomes, causing heterochromatin spreading. This diffusion continues until the remodeling protein reaches a DNA sequence that acts as a barrier. Barrier sequences function by having another histone modification that favors the euchromatin conformation. For example, a common barrier DNA sequence modification is to add an acetyl group to lysine 9 of histone H3. This blocks heterochromatin-induced alteration of methylation at the same lysine residue of histone H3.
Complete question:
Once heterochromatin has been established, it will often spread until it encounters which of the following?
A. a barrier DNA sequence
B. euchromatin
C. histone H3 methylated on lysine 9
D. a nucleosome
E. a gene
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