Crohn's disease, cystic fibrosis, and certain types of cancer are due to frameshift mutations.
What is frameshift mutation?
Frameshift variants might include duplications, deletions, and insertions. There are several places in the DNA where small nucleotide sequences occur repeatedly.
The insertion or deletion of nucleotide bases in amounts that are not multiples of three is referred to as a frameshift mutation in a gene. This is significant because a cell reads the genetic code for proteins in groups of three nucleotides.
Insertions or deletions in the genome that are not multiples of three nucleotides are referred to as frameshift mutations. They are a particular class of insertion-deletion (indel) alterations that are present in polypeptides' coding sequences.
The reading frame may or may not be affected by the insertion or deletion of a nucleotide or combination of nucleotides.
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