Granules from mast cells carry histamine. The initial effects of type I hypersensitivity are a result of histamine release that occurs as they degranulate and that increases vascular permeability and vasodilatation.
In plaque, mast cells are found close to microvessels (77, 78). Mast cells can cause microvessel leakiness and rupture, which can result in intraplaque bleeding, when they degranulate because they release histamine and proteases that break down the matrix.
Abstract. Hypersensitivity is characterized as an excessive or inappropriate immune response, which is typically directed towards harmless antigens and results in tissue damage.
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