The presence of both enzymes for glycogen breakdown as well glycogen synthesis are present in liver thus, it is capable of running glycolysis and gluconeogenesis (gng).
The tissues of some organs, including the brain, the eye, and the kidney, use glucose as their primary or only source of metabolic fuel. Glycogen stores become exhausted during a protracted fast or intense exercise, and glucose must be created from scratch to keep blood glucose levels stable. The process through which glucose is created from non-hexose precursors such glycerol, lactate, pyruvate, and glucogenic amino acids is known as gluconeogenesis.
Glycolysis is effectively reversed during glucose synthesis. However, gluconeogenesis makes use of four distinct enzymes to skip the three highly exergonic (and essentially irreversible) phases of glycolysis.
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