The original parents aren't affected, but several children are affected. this could happen only if the trait were recessive.
At a specific genomic region, an allele is one of two or more variations of the DNA sequence (a single base or a segment of nucleotides). For each genomic region with such variation, an individual inherits two alleles, one from each parent. The person is homozygous for the allele if the two alleles are the same.
Recessive alleles is a particular allele that, when present alone, has no effect on the person. The expression of the trait requires the presence of two copies of the allele. And are mostly appears in offsprings.
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