Across its membrane, there is an electrical potential difference. The resting membrane permeability to potassium is the resting potential.
Within a cell than outside, K+ is more concentrated. Inside the cell compared to outside, organic anions are more concentrated. Outside of the cell, Cl- is more concentrated than inside. Outside of the cell, Na+ concentration is higher than inside.
Sodium channels first open as a result of a stimulus. Sodium ions rush into the neuron because there are many more of them on the outside and because the inside of the neuron is negative in comparison to the outside.
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