Question

in other words, which function, disrupted by mutation, can be provided by a non-defective copy of the retrotransposon elsewhere in the genome for transposition to occur?

Answer 1

One of the long terminal repeats is deleted and Promoter of the retrotransposon is deleted, so the RNA intermediate cannot be made.

What defines a mutation?

A change in the usual DNA sequence at a particular gene locus. Although the term often has a negative connotation, mutations (including polymorphisms) can be harmful, beneficial, or neutral in their effect on cell function.

Is mutation good or bad?

Mutational effects can be beneficial, harmful, or neutral, depending on their context or location. Most non-neutral mutations are deleterious. In general, the more base pairs that are affected by a mutation, the larger the effect of the mutation, and the larger the mutation's probability of being deleterious.

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